It seems we can add you to the 'growing number' of posters in this thread that now have issues! Even if you refuse to ever call them out on it.
Whether there is some new memory limit or not, something they changed is irrefutably affecting (larger?) routes. No, I imagine there wasn't any limit before, hence if there is some kind of one now, what would that make it? It could also very well just be the typical botched coding.
Yes, there could have been something misinterpreted and they meant hardware limits instead, most likely tied to the GPU's VRAM as opposed to system RAM (I can place hundreds of third-party payware rolling stock on a detailed route at max settings without hitting 16GB of RAM, widely considered the bare minimum these days). That doesn't change the fact that if things were working fine in SP5 and don't in SP6 that the hardware isn't the problem.
Either way, the main point is how are we to know? It's been a week now and not a whisper from N3V. No, they don't tend to communicate much here outside of their occasional "We are going to communicate with our userbase now" that might last a couple of weeks before the crickets return, but there is no chance they haven't seen any of these responses on their own release thread.