At the risk of being a dumb question... The selection says TS2004 but I acknowledge that immediately after that in brackets it has (Trainz.exe). Do the settings then apply to any copy of trainz.exe on the PC. I have three TS12 installations and a single TS10.It is not the meshes as I stated before - Here is the solution that corrected this issue for me.
It is Driver Related............
Was driving me nuts with my LOD Grass Mesh that compliments my textures and other assets
The "Scan for games" option in NVidia Force Experience doesn't find Trainz and its not listed in their list of supported games. Hopefully that may improve after T:ANE.
I'll try out your settings anyway,