(single R click on the TRS2006 Desktop icon) Try opening the TRS2006 File, and by going into the TRS2006 files/bin, and dbl L click on the TPS2006 icon. See if it starts working. If error messages, or US lang errors come up...it needs fixing...but it is easy...I deleted all of the other TPS foriegn lang files, and left the US lang file intact.
Like I said earlier TRS2006 Paintshed is an extremely limited progam, that can only do a dozen or so locomotives and cars...and virtually nothing can be imported into it (besides photos, textures, cut and paste RR emblems...etc...). Mine worked...then I broke it somehow, because I uninstalled TRS2006 several times...Eventually I uninstalled it...and re-downloaded it from a site....I think it was GAURC.
It does a fairly good job painting and renumbering locomotives, and cars.
I did my PRR-TGV in it....and it is available on DLS.
Let us know how you make out fixing it. so it works.