What I've done in the past is to scale up or down images of model layouts so they fit across a 1k x 1k Basemap, or divide the image up so it fits across as many as it takes.
I then lay the rail and landscape the route. It can take as much work as you want to put into it.
Recently I did the Scenic and Relaxed, which I plan to upload to the DLS at some point. I tried awhile ago, but had some technical difficulties which got in the way and then I got busy.
Wherever the land wasn't used, I sculpted it down and darkened it so it was as though the layout was sitting on a foam base. I used backdrops to hide the hinder land where nothing was located.
When viewing and driving the little route, it's almost like seeing my old N-scal model railroad when I built it many years ago. The only difference is there was no plaster, glue, and a mess to clean up.
What was interesting is I had similar issues with the track layout on the virtual route as I did on the real thing. There's a small yard at the front, but the track layout is awkward to work with. In the 1:160 route I had, I added a few extra turnouts and crossovers, and this helped quite a bit. The problem though had to do with the approach grade to the yard throat being steep and affecting the turnouts. The issue was the same with the virtual model railroad, and now I can see this program as an important tool for model railroad testing before the first spike is laid, or plywood cut.


http://img718.imageshack.us/i/jcitron200910270004.jpg/
http://img251.imageshack.us/i/jcitron200910270003.jpg/


http://img715.imageshack.us/i/jcitron200910270001.jpg/
http://img251.imageshack.us/i/jcitron200910270000.jpg/
John