I am now creating only in Trainz Plus (which is also on your timeline). TRS22 is functionally the same as Trainz Plus for those who have both versions so I suppose it does not really matter between the two.
Of course this is only my opinion but TRS19 is now 4 years old (or more if you consider that it came out towards the end of 2018). For me the addition of Surveyor 2.0 in Trainz Plus is the real TRS19 killer. However, there are plenty of creators still working in T:ANE and even earlier versions.