I have run it on one Windows 10 (64Bit) machine recently but not on another both of which are a few years old and below the graphic specification required by T:ANE. Fiddling with Windows compatibility mode etc. made little difference in fact I found it ran better on Linux. If as in my case you are thinking of using a second, perhaps spare machine, and not your main computer, and assuming you have a Windows 10 production key you may be able to download a 32Bit version of Windows from Microsoft and do a fresh install to experiment with. Peter