Some routes may work after going through the process of updating the assets and such. The main issue you will encounter, and it's a big one, is that Speedtrees from that era won't work past 12. Any routes which utilize speedtrees will need to have those trees/bushes/etc replaced in 12 for assets compatible with the newer editions before moving them over. This can be quite the time-consuming endeavor depending on the size of your routes. It's been years since I've attempted this (and I never went straight to '22 without passing them through T:ANE first), so perhaps some shortcuts have been found to speed up the process, but they will still need to be swapped-out one way or the other. Not sure about the signals.