TRS2006 and TS2009 run fine in Vista 64-bit. You'll need to install and run the program as an Administrator so that the files will be written properly.
The programs run even better under Windows 7, which is the next generation of Vista. (My opinion). It loads quickly and the response is very nice overall.
By habit and virtue of being a system guru, I installed TS2009 with Admin settings in W7 also just to make sure I wouldn't have any problems.
John