With regard to Transdem routes, don't forget it is essential to apply the route filter, not extract the whole DEM area. You can bring this down to as few boards as you feel will provide the necessary background scenery/distant mountains without revealing the edge of the world. Transdem also allows you to export just the course of the route as 5m grid with the remainder as 10m (good enough for simple texturing) which saves on the .gnd file size considerably.
As a rule of thumb, I extract to around 5 "boards" either side of the route in relatively level country and 6 or 7 in the hills, trimming later as required. However the file sizes can still come out huge using this approach. A recent narrow gage venture covering around 100 miles, comes in at around 450Mb before anything other than the Transdem textures are applied. Although well within the limits kindly stated by Gawpo50, I've decided to put this one on hold (along with the similar length tundra route) until TANE as even though within workable limits, it still takes an age to save and pointless doing work that may be lost if the project becomes unstable.