Sorry to hear of your loss. With the mourning period over and coming to grips with what to do going forward, let me give you some tips.
First of all I believe in the KISS method. Yes if there's a quick, no brainer, way of doing something I will seek it out.
With that said, here's what I've done.
1) I put my TRS19 data on a separate hard disk away from the system drive. This ensures that the data is easily accessed because it's out of the confoundingly awful users/..../app data path!
I setup my data folder on my E: Drive and called it TRS19_Data.
This allows for easy access to the User Data/editing folder for content repairs so much easier.
It allows for data integrity and safety because if there's a system issues, which require a system cleanup or reinstall, then the data is still safe and it's a matter of reinstalling programs and there's no data loss.
2) I use a simple copy method for backups using a program called Fast Copy.
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https://fastcopy.jp/en/
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This has a bunch of options, which I use the barest number to get the job done. Increase the amount of RAM allocated to copying (it's a buffer), and most importantly, I backup my E:\TRS19_DATA folder to my BACKUPs folder on my external Seagate Desktop drive.
The full backup is run frequently, with differential backups done in between, or about once or twice a week and more frequently if I've been Trainzing more often, and the process runs overnight. When I'm up the next morning, the backup is done and I'm good to go. Since the data is copied and not compressed or turned into an unusable format outside of the backup software, accessing the backups can be done in a snatch, and should Fast Copy not work for some reason, the data can still be copied back again using File Manager in Windows.
Others may recommend synching data with the cloud, but given the huge amount of content we have, that can rack up some hefty disk space and expenses. The other issue with sync'ing is there's a possibility of overwriting a good backup with bad data.
In the end, pick a method that works for you and keep the KISS method in mind. The fewer steps and fewer convoluted processes means a much easier and simpler process to handle.