HDT is very system resource intensive. Try increasing your page file to at least 1.5 times the amount of RAM you have installed on your motherboard.Since SP5 and beyond my game was intermittent crashing also. I turned the shaders down to basic and it stopped the crashing. It seems to be a problem with HDT in some way. And I have all the updates for my card and it was flawlessly running with details and shadows high before SP5. Hope the next patch cures the problem!