Hi,
For 2006 I delete the route & dependencies like this:-
Open CMP, search form "location = local" + "category = routes" and select the route to be deleted.
Right click select "show dependencies" from the menu. This list them in a pop-up window.
Now use th e button "view in main screen" - and all of the dependencies are listed. Control-A (or select all), then "delete" - and they are gone.
Now return to the CMP list of routes, select the route and delete that.
You will receive error messages if you try to delete built-in content - these can be ignored.
The only problem is that you may delete a dependency that's used by another route... You won't find out until you look at all the routes you have installed and look for the missing dependency flag (or try to load the route).
One way of reducing the impact is to Archive the route + dependencies (create a new archive for deleted routes). Carry on as before - deleting everything - if you need a deleted asset CMP will pull it from the archive. Once you're happy that the archive isn't needed you can delete it - this saves you re-downloading.
HTH
Colin