Is there a way to view a sort of crash log? the source of the problem may be able to be located with that
Click on Settings and then on Dev tab. Ensure the advanced debug tools is checked.
Close that.
Click on Developer on the menu bar.
Click on show logs and scroll through looking for an error. You might see something, but you might not.
I recommend creating an empty database to see if there's still more crashes and to rule out the program being corrupted or not. If it doesn't well you'll have to do a fresh install, if it runs fine then it's the data that's bad.
Go into settings on the Launcher:
Click on Install tab.
Make note of where your data is located because you will need to know this for later.
blank out that information.
Restart T:ANE as prompted, close the launcher too and start again after a minute or two.
You'll have to reenter in your username and password and setup any graphics settings since this is a fresh installation just like everything was first setup.
When you go into the game, if it launches you'll download any additional routes from the DLC server, but your custom stuff isn't there, just remember that, because this is like a fresh install.