I don't have a Mac but a few questions that might help.
By "simple" throttle I assume that you mean using the "W", "S" and "X" keys? Do other keys work correctly? Are you using a wireless keyboard?
Is this a new install? Have you had TRS22 installed before and did not experience this issue?
Does this occur with other locos, or is it just a specific one?
Is the loco with a consist parked at an industry?