The Muleshoe line (Hollidaysburg to Tunnelhill) was the original PRR Mainline prior to the Horseshoe being opened in 1854.
Basicly Kittanning Station, Coaling Transfer Tower, and interlocking there at MP 241.37 was torn out in the very early 1900's. At that time when these did exist, the Horseshoe was only 2 tracked (it was originally 1 track in 1854).
On the "Long Straight" @ 2 miles east of the Horseshoe was the site of long tank track water pans, for PRR tenders to take on water on "the fly".
This is what the Curve area looked like in the very early 1900's (originaly single tracked), it was soon 2 tracked.
Later on it was 3 tracked, and then later on 4 tracked.
In the late 1990's the Gift Shoppe, ice cream stand, flagpole, steps and the gazebo were torn out, and replaced by a funicular, and modern steps and gft shop.
The old "S" curved winding road was also relocated as per your screenshot in the late 1990's
So Kittanning Station and Interlocking was all torn out prior to the 1920's.
I would keep the station there, as I like to mix eras (you or the end user can always take it out at a later date) ... I might even keep the interlocking just for fun, and add 2 more tracks around the Curve. Also the 3 Coal & Lumber branches, the temporary park engine track, Glenwhite Coal & Lumber spur could be left there, or converted to railbed only track.
I still have to research Alto Interlocking, as I believe in the 1920's to 1930's it was known as "BO" Tower, and the switch araingement was constantly being changed.
As for the 17+ Altoona freight yards ... I wold not sweat the small stuff ... I would recommend making it just one big yard ... it was most complex trackage.
Laying the turnouts on Slope yard which has a 1.22% gradient was a nightmare, I had to level the turnout spline points with "water" as a guide (moving it up and down) ... Altoona yards are on a 0.41% gradient.
I will post screenshots and diagrams soon:
http://i525.photobucket.com/albums/cc339/cascaderailroad/AltoonaWest.jpg
http://i525.photobucket.com/albums/cc339/cascaderailroad/AltoonaEast.jpg
I have color coded the passenger main Red, as it deverged at Antis, and criss crossed undrneath the WB Classification Yard at Homer.
The freight mains (Green) serpintined through the middle of the yards to Rose.
The other EB Freight Classification and Scale tracks sorted thousands of loaded coal hoppers per day, ending up on the departure tracks in Brush Yard.
Best viewed at 150% zoom or greater