In addition to CDP backups of favorite routes, especially your own, copy your all of your Trainz content to an external drive. Once a week, I copy my TRS2019 content located on my "E" drive to my backup external drive.
A full backup takes 4 hours so I do it overnight, but a differential backup takes about 45 minutes. I will do the full backup monthly, and then the in between differential backups, which only capture stuff that changed, once a week.
By doing this, I've been able to transfer everything, lock, stock, and barrel to another drive or even another computer without missing or losing anything I've been working on. If I use my laptop, such as when I used to travel, I would copy over, via CDP, only the route(s) I modified.
It's because of this, I was able to avert two very serious hard drive incidents and recovered nearly Scott free without any data loss.