Yes, I have had this annoying problem in 98592 since downloading recent 'built in' and 'payware' updates, also in TANE when these same assets were updated. It might have something to do with the faulty 'portal basic', which I hope has been put right in the new build of TRS19. This was identified as faulty when I checked trainz log, but is not ahown as such in content manager.
ingha
Update: This is still happening in build 100240. I edit a route or a session and then get a blank screen and have to restart the computer, or the computer restarts itself. Either way this is a serious problem, and began with the recent 'built in' and 'payware' assets updates.