I did have 64GB installed in my current system. I have a bad DIMM which had me reduce the memory to 32GB in order to keep the pairs consistent, however, even this extra memory does help. The modern 64-bit operating systems are "smart" and make use of the extra RAM on board unlike the old 32-bit OS which wouldn't see anymore than 4GB anyway even if more was installed.
With the extra memory installed, more than one application can run without the programs constantly fighting for space, which means I can have T:ANE, TransDEM, Google Earth Application, and a browser open at the same time. The video card, even with its 11.5 GB of onboard DRAM, still makes use of system RAM, so having the extra RAM in the system doesn't hurt.
There are a couple of programs available from Microsoft's TechNet, which help us see the resources. Look for RAMMAP and Process Explorer.