Look in the Extras folder where the T:ANE program is installed. There's a user manual, albeit, a bit thin.
To create a session in a quick overview.
At the routes menu, click on your route.
Click on View Sessions on the lower right.
Click on Create session. From this point on, if you want to change your session after you've exited, use Edit Session located at the bottom of the screen.
Place some trains.
Save and put in a name you'll remember like route-name-driving session. (It's always good to save and we'll do this often.)
Click on the Edit Session rules along the upper edge of the screen.
Click on Driver Setup (Driver Setup)
You'll see drivers assigned to your locomotives.
There's an additional option in T:ANE which was not in TS12 - Remove all existing Drivers first.
I recommend doing this and removing any extra drivers who happened to be assigned to other locomotives around the route like those in an engine terminal for example because you can always assign drivers later as needed. This is optional so it's not necessary, but something to keep in mind.
Back to the drives shown...
You see the blue arrow things... Click on those and add in your commands like drive to track mark named whatever, (You did place track marks?). Drive to station load, etc.
Once all of these are done.
Save.
Exit the editor.
Now drive the session.
Hope this helps. There's a lot of other stuff you can do, but these are the basics which have been this way since at least TRS2009.